CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents.

作者: Robert Milne , Hugo Albrecht , Shudong Wang , Abel Tesfaye Anshabo

DOI: 10.3389/FONC.2021.678559

关键词:

摘要: Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions, most importantly cell division and transcription, and their dysregulations have been …

参考文章(247)
Scott H. Kaufmann, Judith E. Karp, Phyllis A. Svingen, Stan Krajewski, Philip J. Burke, Steven D. Gore, John C. Reed, Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse Blood. ,vol. 91, pp. 991- 1000 ,(1998) , 10.1182/BLOOD.V91.3.991.991_991_1000
Christopher Abdullah, Xiaolei Wang, Dorothea Becker, Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma. Cell Cycle. ,vol. 10, pp. 977- 988 ,(2011) , 10.4161/CC.10.6.15079
S G T Devaraj, W Fiskus, B Shah, J Qi, B Sun, S P Iyer, S Sharma, J E Bradner, K N Bhalla, HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist Leukemia. ,vol. 30, pp. 504- 508 ,(2016) , 10.1038/LEU.2015.142
Y. Gu, J. Rosenblatt, D.O. Morgan, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. The EMBO Journal. ,vol. 11, pp. 3995- 4005 ,(1992) , 10.1002/J.1460-2075.1992.TB05493.X
Elisabeth Walsby, Guy Pratt, Hao Shao, Abdullah Y. Abbas, Peter M. Fischer, Tracey D. Bradshaw, Paul Brennan, Chris Fegan, Shudong Wang, Chris Pepper, A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Oncotarget. ,vol. 5, pp. 375- 385 ,(2014) , 10.18632/ONCOTARGET.1568
L A Chodosh, A Fire, M Samuels, P A Sharp, 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro Journal of Biological Chemistry. ,vol. 264, pp. 2250- 2257 ,(1989) , 10.1016/S0021-9258(18)94169-4
Van Trung Nguyen, Tamás Kiss, Annemieke A. Michels, Olivier Bensaude, 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes Nature. ,vol. 414, pp. 322- 325 ,(2001) , 10.1038/35104581
D D Kephart, N F Marshall, D H Price, Stability of Drosophila RNA polymerase II elongation complexes in vitro. Molecular and Cellular Biology. ,vol. 12, pp. 2067- 2077 ,(1992) , 10.1128/MCB.12.5.2067
Huasong Lu, Yuhua Xue, Guoying K Yu, Carolina Arias, Julie Lin, Susan Fong, Michel Faure, Ben Weisburd, Xiaodan Ji, Alexandre Mercier, James Sutton, Kunxin Luo, Zhenhai Gao, Qiang Zhou, None, Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism eLife. ,vol. 4, ,(2015) , 10.7554/ELIFE.06535
Frédéric R. Santer, Holger H. H. Erb, Su Jung Oh, Florian Handle, Gertrud E. Feiersinger, Birgit Luef, Huajie Bu, Georg Schäfer, Christian Ploner, Martina Egger, Jayant K. Rane, Norman J. Maitland, Helmut Klocker, Iris E. Eder, Zoran Culig, Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy Oncotarget. ,vol. 6, pp. 6105- 6122 ,(2015) , 10.18632/ONCOTARGET.3368