Non-cardiovascular effects associated with statins

摘要: Statins form the pharmacologic cornerstone of primary and secondary prevention atherosclerotic cardiovascular disease. In addition to beneficial effects, statins seem have multiple non-cardiovascular effects. Although early concerns about statin induced hepatotoxicity cancer subsided owing reassuring evidence, two most common that clinicians are myopathy diabetes. Randomized controlled trials suggest associated with a modest increase in risk myositis but not myalgia. Severe (rhabdomyolysis) is rare often linked regimen no longer recommended (simvastatin 80 mg). meta-analyses an diabetes statins, particularly higher intensity regimens people or more components metabolic syndrome. Other effects covered this review contrast nephropathy, cognition, cataracts, erectile dysfunction, venous thromboembolism. Currently, systematic reviews clinical practice guidelines indicate benefits generally outweigh harms patients above certain threshold risk. Literature also accumulating on potential which could lead novel applications class drug future.