Antimicrobial stewardship: concepts and strategies in the 21st century
作者： Robert C. Owens
DOI: 10.1016/J.DIAGMICROBIO.2008.02.012
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摘要: Large worldwide surveillance studies report that resistance to nearly all classes of antimicrobial is increasing, as is the emergence of what have been termed pan-drug–resistant and extremely drug-resistant pathogens. Concomitantly, bacterial binding sites have been exploited by available antimicrobials, and there has been a decline in the development of antimicrobials using novel mechanisms of action. These trends have prompted healthcare facilities to adopt antimicrobial stewardship programs (ASPs) and …
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