Molecular and cellular biology of the human reduced folate carrier.

摘要: The natural folates are water-soluble members of the B class vitamins that essential for cell proliferation and tissue regeneration. Since mammalian cells cannot synthesize de novo, tightly regulated sophisticated cellular uptake processes have evolved to sustain sufficient levels intracellular tetrahydrofolate cofactors support biosynthesis purines, pyrimidines, serine, methione. Membrane transport is also a critical determinant antitumor activity antifolate therapeutics (methotrexate, Tomudex) used in cancer chemotherapy, impaired antifolates frequent mode drug resistance. reduced folate carrier major system classical tissues. This review summarizes remarkable advances molecular biology human over past decade, relating its structure function, mechanisms transcriptional posttranscriptional regulation, role response Many key vitro findings now begun be extended studies function patient specimens, paving way translating basic laboratory cultured improvements health treatment disease. results research into should clarify roles changes expression this accompany nutritional deficiency disease, may lead improved therapeutic strategies enhancing circumventing resistance patients undergoing chemotherapy with antifolates.