THE EFFECT OF HYPERTONIC RESUSCITATION ON PIAL ARTERIOLAR TONE AFTER BRAIN INJURY AND SHOCK

摘要: Acute brain injury followed by hemorrhagic shock (HEM) causes prohibitive mortality in trauma patients because these combined events lead to low cerebral blood flow (CBF) and oxygen delivery (co 2 del). Proper treatment therefore requires rapid correction of perfusion deficits. Previous studies have shown that hypertonic crystalloid resuscitation significantly improves CBF co del a model HEM when compared lactated Ringer's (LR) solution. The mechanism or mechanisms for this advantage, however, are not well understood. We hypothesized fluid would reduce pial arteriolar tone after resulting an increase LR