Organocatalytic Asymmetric Mannich Reactions: New Methodology, Catalyst Design, and Synthetic Applications
作者： Amal Ting , Scott E. Schaus
关键词:
摘要: The direct, asymmetric Mannich reaction catalyzed by small organic molecules offers a facile route to optically active α- or β-amino acid derivatives and 1,2- γ-amino alcohols. One-pot reactions of unmodified carbonyl donors with preformed in situ generated imines can be stereochemically controlled Organic catalysts such as proline, chiral pyrrolidines, Bronsted acids, Cinchona alkaloids. adducts further functionalized towards variety bioactive molecules. In this Microreview, recent contributions are discussed present the methodology synthetic advantages achieved so far reaction. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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