Beneficial Effect Administration of Vitamin C in Amelioration of Lead Hepatotoxicity

摘要: Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipid. Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for toxicity. The protective action vitamins C against affects hydroperoxide level liver functions in male rats studied. Experiments were performed on waster body weights 120-160 g. Male wistar exposed to 3 g/l acetate drinking water 5 weeks treated thereafter vitamin (500 mg/kg, orally) 28 days. One day after feeding was over, venous blood samples, under chloroform anesthesia, collected. animals killed by exsanguinations excise determination metal content histopathological changes. Similarly, tissue (lipid peroxidation) enzyme fraction (superoxide dismutase (SOD), catalase (CAT), alkaline phosphatase (ALP), acid (ACP) glutathione (GSH) also measured liver. Metal determined means atomic absorption spectrophotometry. Administration (3 g/l) induced a significant increase levels hepatic ALP, ACP peroxidation. Lead produced detrimental effects redox status indicated decline antioxidants such SOD, CAT GSH. Further, there lead. However, oral administration at dose 500 mg/kg weight reduced alterations previous parameters. Histological examination revealed pathophysiological changes acetate-exposed group treatment improved histology. result this study strongly indicate got potent antioxidant damage rats.