Skin-permeable selective cyclooxygenase-2 inhibitor composition
作者： Ashwini Gadre , Praveen Tyle , Guang Wei Lu , Brenda M. Stoller , Rajeev Gokhale
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摘要: A dermally deliverable pharmaceutical composition comprises at least one selective cyclooxygenase-2 (COX-2) inhibitory drug or prodrug thereof solubilized in a pharmaceutically acceptable carrier that low molecular weight monohydric alcohol, and exhibits skin permeation rate of the therapeutic agent equal to exhibited by reference solution 70% aqueous ethanol. method effecting targeted delivery COX-2 site pain and/or inflammation subject topically administering such subject, preferably locus overlying adjacent inflammation. systemic treatment having mediated disorder transdermally composition, contacting with an area not greater than about 400 cm2.
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