The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract.

摘要: Acetaldehyde has been classified as a carcinogen in experimental animal research. is highly toxic, mutagenic and carcinogenic. causes point mutations, sister chromatid exchanges gross chromosomal aberrations. In the liver, acetaldehyde binds to DNA formation of stable adducts represents one mechanism by which could trigger occurrence replication errors and/or mutations oncogenes or tumour suppressor genes. colorectal carcinogenesis inhibition dehydrogenase with elevated levels results an acceleration cancer development. The production reduced when germ-free animals are studied, emphasizing role bacteria generation acetaldehyde. colorectum correlate crypt cell rate result hyper-regeneration, precancerous condition. Genetic linkage studies give further evidence for carcinogen. Individuals who accumulate due polymorphism genes coding enzymes responsible detoxification have increased risk. This true Asians low 2 Caucasians alcohol 1C*1/1. conclusion, there enormous body from vitro studies, experiments genetic that major factor development alcohol-associated gastrointestinal tract.