New neurons for injured brains? The emergence of new genetic model organisms to study brain regeneration.
作者： Ismael Fernández-Hernández , Christa Rhiner
DOI: 10.1016/J.NEUBIOREV.2015.06.021
关键词:
摘要: Neuronal circuits in the adult brain have long been viewed as static and stable. However, research past 20 years has shown that specialized regions of brain, which harbor neural stem cells, continue to produce new neurons a wide range species. Brain plasticity is also observed after injury. Depending on extent permissive environment neurogenic regions, different organisms show great variability their capacity replace lost by endogenous neurogenesis. In Zebrafish Drosophila, formation from progenitor cells was only discovered recently. Here, we compare properties niches regenerative responses mammals flies. Current models injury revealed specific injury-induced genetic programs comparison neuronal fitness are implicated repair. We highlight potential these recently implemented regeneration identify novel regulators cell activation
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