Hyperinsulinaemia: A prospective risk factor for lethal clinical prostate cancer

摘要: Abstract Previous studies have suggested that hyperinsulinaemia and other components of metabolic syndrome are risk factors for clinical prostate cancer. This prospective study tested the hypothesis lethal The clinical, haemodynamic, anthropometric, insulin profile at baseline in men who had died from cancer during follow-up was compared with were still alive follow-up. If is true, an unfavourable prognosis would a higher than those favourable prognosis. A total 320 patients whom cancer, stages T2–3, been diagnosed consecutively included 1995–2003. Height, body weight, waist measurement, hip measurement blood pressure determined. Body mass index waist/hip ratio (WHR) calculated. Blood samples collected to determine triglycerides, cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density (LDL)-cholesterol, uric acid, alanine aminotransferase fasting plasma level. gland volume measured using transrectal ultrasound. annual benign prostatic hyperplasia (BPH) growth rate diagnosis established ultrasound-guided automatic needle biopsy gland. All followed up until their death or terminated on 31 December 2003. At follow-up, 54 219 alive. results showed period older ( P  = 0.028) prostate-specific antigen (PSA) level  = 0.027),  = 0.004), WHR  = 0.097) borderline significance acid  = 0.079) significance. Eliminating effect mortality stage grade PSA baseline, following statistically significant correlations remained:  = 0.010) lower HDL-cholesterol  = 0.065). In conclusion, five previously shown be deaths can ascribed These findings confirm previous study, which indicate component syndrome. Moreover, these data disorders precede caused by Thus, our support promoter Furthermore, suggest could used as marker tumour aggressiveness, regardless patient’s stage,