No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
作者： Il-Soo Kim , Ho-Kyoung Yoon , Seung-Gul Kang , Young-Min Park , Yong-Ku Kim
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摘要: Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) key ligand dopamine D2 receptor, Par-4 gene (PAWR) good candidate to study in context TD susceptibility. We examined association between PAWR polymorphisms and TD. Three single nucleotide were selected for analysis: rs7979987, rs4842318, rs17005769. Two hundred eighty unrelated Korean schizophrenic patients participated this (105 175 non-TD patients). Genotype/allele-wise haplotype-wise analyses performed. There no significant differences genotype allele frequencies two groups. Haplotype analysis also did not reveal difference Within limitations imposed by size clinical sample, these findings suggest that variants do significantly contribute an increased risk
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