Pathology Analysis of the Placenta

摘要: Chapter Summary Placental abnormalities (with or without additional lesions in the embryo) are a frequent cause of gestational mortality. Thus, properly designed pathology analysis to investigate novel embryolethal phenotype must include an appropriate placental assessment. Evaluation mouse requires thorough understanding normal macroscopic (gross) and microscopic features organ anatomy; differences morphology among various strains; common patterns tissue, cellular, molecular damage that can negatively impact function. A useful analytical strategy for placenta is grossly examine unfixed organs at necropsy obvious changes consistency, color, shape, size, after which representative samples processed permit histopathological evaluation. Any described easily discerned subregions: chorioallantoic plate, labyrinth, spongiotrophoblast, giant cell trophoblast, decidua. Structural may be correlated with expression data define pathogenesis defect. The key successfully performing examination conduct systematic manner across all studies so pathologist gains accurate morphology, as well primary fashions structures become distorted embryonic death becomes preferred outcome.