Update on genetic markers of quinine resistance in Plasmodium falciparum.

摘要: The emergence and spread of antimalarial resistance remain burgeoning issues. Any strategy to slow down or overcome these problems requires an understanding the genetic changes underlying this resistance. Quinine, first antimalarial, has been central in treatment severe malaria, proposed as second line for uncomplicated malaria many African countries. Some reports have indicated quinine South East Asia Africa, however doubts raised about Africa. New interesting data are emerging on mechanism reduced susceptibility. In report, we reviewed work vivo efficacy vitro activity quinine, discussed recent markers drug. Overall, still remains efficacious pfnhe, sodium hydrogen exchanger, may be one