Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis.

摘要: Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL synthesis. very low density lipoprotein (VLDL) (LDL) Hyperlipidemia is hallmark of syndrome that has been associated with risk for ischemic heart disease as well loss renal function these patients. The hyperlipidemia usually characterized by cholesterol levels, although hypertriglyceridemia may be present well. factors determine the phenotype dyslipidemia are not understood, nor primary stimulus identified. One hypothesis result coordinate increase synthesis proteins liver. To address issues we simultaneously measured vivo rate apolipoprotein B100 (apo B100) secretion, apo and albumin (N = 8) compared them control group 7) using primed/continuous infusion stable isotope L-[1-13C] valine six hours. Kinetic data were analyzed multicompartmental analysis. Patients studied had combined reflected an significant both pool sizes. In contrast, size was significantly decreased. levels primarily consequence decrease fractional catabolic (FCR) rather than absolute (ASR). Both triglycerides inversely related to (r2= 0.708; P 0.0088) neither any relationship ASR B100. contrast VLDL, catabolism. (P 0.001) controls. Low greater some patients, suggesting only derived delipidation, but also alternative secretory pathway. There no clear between within current study population. Our indicate catabolism,