Investigation into Hepatoprotective Activity of Citrus limon.
作者： Shefalee K. Bhavsar , Paulomi Joshi , Mamta B. Shah , D.D. Santani
DOI: 10.1080/13880200701214995
关键词:
摘要: AbstractThe current study was designed to investigate the effect of Citrus limon. (L.) Burm. (Rutaceae) fruits, commonly known as lemon, in experimental liver damage. The ethanol extract fruits evaluated for its effects on damage induced by carbon tetrachloride, and ethyl acetate soluble fraction HepG2 cell line. normalized levels aspartate aminotransferase (ASAT), alanine (ALAT), alkaline phosphatase (ALP), total direct bilirubin, which were altered due tetrachloride intoxication rats. In tissue, treatment significantly reduced malondialdehyde (MDA), hence lipid peroxidation, raised antioxidant enzymes superoxide dismutase (SOD) catalase. It improved glutathione (GSH) treated rats comparison with CCl4-intoxicated histopathologic studies, animals exhibited restoration t...
informahealthcare.com参考文章(30)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
S. V. S Rana, K. Taketa, Liver And Environmental Xenobiotics ,(1997)
Hara P. Misra, Irwin Fridovich, The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase Journal of Biological Chemistry. ,vol. 247, pp. 3170- 3175 ,(1972) , 10.1016/S0021-9258(19)45228-9
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Naveen Tirkey, Sangeeta Pilkhwal, Anurag Kuhad, Kanwaljit Chopra, Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney BMC Pharmacology. ,vol. 5, pp. 2- 2 ,(2005) , 10.1186/1471-2210-5-2
Vincenzo De Feo, Rita Aquino, Alessandro Menghini, Eliseo Ramundo, Felice Senatore, Traditional phytotherapy in the Peninsula Sorrentina, Campania, Southern Italy Journal of Ethnopharmacology. ,vol. 36, pp. 113- 125 ,(1992) , 10.1016/0378-8741(92)90010-O
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
Yoshiaki Miyake, Kanefumi Yamamoto, Nobuko Tsujihara, Toshihiko Osawa, Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids. ,vol. 33, pp. 689- 695 ,(1998) , 10.1007/S11745-998-0258-Y
F.M. Vázquez, M.A. Suarez, A. Pérez, Medicinal plants used in the Barros Area, Badajoz Province (Spain) Journal of Ethnopharmacology. ,vol. 55, pp. 81- 85 ,(1997) , 10.1016/S0378-8741(96)01491-2
Regina Bruggisser, Katrin von Daeniken, Gernot Jundt, Willi Schaffner, Heide Tullberg-Reinert, Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay Planta Medica. ,vol. 68, pp. 445- 448 ,(2002) , 10.1055/S-2002-32073