Noninvasive assessment of airway alterations in smokers: the small airways revisited.

摘要: It has been shown that structural changes in small airways of smokers with average smoking histories greater than 35 pack-years could be reflected the single-breath washout test. The more sophisticated multiple breath test (MBW) potential to anatomically locate affected acinar and conductive lung zones through increased phase III slope indices Sacin Scond, respectively. Pulmonary function, Sacin, Scond were obtained 63 normal never-smokers 169 classified according history ( 30 pack-years). Compared never-smokers, significant (p = 0.02), < 0.001), diffusing capacity (DLCO; p 0.001) detected from 10 onwards. Spirometric abnormality was only 20 In DLCO less 60% predicted, presence emphysema resulted dispropo...