Regioselective Metabolism of Taxoids by Human CYP3A4 and 2C8: Structure-Activity Relationship
作者： Thierry Cresteil , Bernard Monsarrat , Joelle Dubois , Michelle Sonnier , Paul Alvinerie
DOI: 10.1124/DMD.30.4.438
关键词:
摘要: … structure, the two drugs are oxidized by two different enzymes; CYP2C8 catalyzes the 6-hydroxylation on the taxane ring of paclitaxel, whereas CYP3A4 … supported by CYP3A4. The …
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