Upper airway resistance syndrome: effect of nasal dilation, sleep stage, and sleep position.

摘要: BACKGROUND: The upper airway resistance syndrome (UARS) is one of the mild variants obstructive sleep disordered breathing. Nasal obstruction proposed as mechanisms that lowers intrapharyngeal pressure and hence increases collapsibility. OBJECTIVE: We evaluated effect external nasal dilation position on in UARS. METHOD: A double blind, randomized, controlled study with a crossover design (using therapeutic placebo dilators) was conducted 18 consecutive patients Each patient had two overnight studies to weeks apart. Cardiorespiratory parameters (AHI, percentage time SaO2 more than 2% below awake [desaturation time] mean heart rate), architecture (sleep stages, efficiency, arousal index), body were determined. RESULTS: Application dilator resulted significant increase cross-sectional area (p < 0.001). Treatment reduced stage 1 (as percent total time) from 8.6 +/- 0.8% 7.1 0.7 (SEM), p = 0.034). Desaturation significantly lower treatment (12.2 2.2% versus 9.1 1.3 treatment, 0.04). There no additional effects cardiorespiratory parameters, architecture, or MSLT when entire night examined. Controlling for interactions we found desaturation 0.03) but not AHI index. lateral compared supine 0.0001) NREM REM 0.002) 0.006). Arousal index highly dependent 0.0001): higher 2 slow wave REM. Sleep arousals. CONCLUSIONS: External sleep, an indirect marker disrupted time. Both breathing