What fires prometheus? The link between inflammation and regeneration following chronic liver injury.

摘要: Liver progenitor cells (LPCs) play a major role in the regeneration process after chronic liver damage, giving rise to hepatocytes and cholangiocytes. Thus, they provide cell-based therapeutic alternative organ transplant, current treatment of choice for end-stage disease. In recent years, much attention has focused on unravelling cytokines growth factors that underlie this response. following acute damage is achieved by proliferation mature hepatocytes; yet similar cytokines, most related inflammatory process, are implicated both regeneration. many studies represent attempts identify LPC-specific factors. This review summarises our understanding LPC biology with particular focus response being associated induction LPCs liver. We will describe: (i) pathways damage; (ii) similarities differences between two pathways; (iii) environment; (iv) unique features immunology as well (v) interactions immune LPCs. Combining data from LPC-driven knowledge field improve allow us regulate these vivo vitro future strategies treat