Effect of truncated neurokinin-1 receptor expression changes on the interaction between human breast cancer and bone marrow-derived mesenchymal stem cells
作者： Yunli Zhou , Duo Zuo , Meng Wang , Yongci Zhang , Man Yu
DOI: 10.1111/GTC.12168
关键词:
摘要: Previous studies in breast cancer cell lines showed that truncated neurokinin receptor-1 (NK1R-Tr) was able to promote malignant transformation of cells, and NK1R-Tr may contribute tumor progression distant metastasis human cancer. A co-culture model bone marrow-derived mesenchymal stem (HMSC-bm) cells HMSC-bm inhibited the growth entered marrow at early stages. Down-regulation be a key factor maintaining quiescent phenotype among stroma. Stromal-derived (SDF)-1α expression negatively correlated with cells. Secretion SDF-1α by maintain stroma down-regulating expression. Transforming (TGF)-β1 positively associated In system, MDA-MB-231-TGF-β1I (TGF-β genes were suppressed using specific shRNA) attach quickly, indicating TGF-β1 also for However, detailed mechanism still remained unclear could involve other molecules, addition NK1R-Tr.
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