Multinuclear NMR of Calcium Fructoborate Complex – Structure, Stability, and Quantitation in the Presence of Other Ingredients, Excipients or Adulterants

摘要: FruiteX-B®- calcium fructoborate (FrxB) plant mineral complex was investigated in this study. Although is naturally-occurring and found commonly ingested fruits vegetables, the commercially produced FrxB formed by a proprietary reaction of boric acid with fructose carbonate. Liquid solid-state 13C 11B NMR were utilized order to establish baseline standard for product quality purposes, reliable methodology positively identify quantify amounts present tablets capsules, liquids powdered blends wherein may have been mixed other ingredients, excipients, or adulterants such as maltodextrin magnesium stearate, robust testing method identification quantification mono- di-complexes well any free borate and/or that be present. The molar ratio various components studied relative borate, fructose, mono-ester/di-ester material. A quantitative developed enable amount products it had tableted encapsulated combination dietary supplement excipients stearate maltodextrin. content complex. Finally, an based stability study performed monitor molecular level at temperatures ranging from 35-70 oC exposures lasting 2-18 hours.