Genetic and Metabolic Determinants of Fatty Acid Chain Length and Desaturation, Their Incorporation into Lipid Classes and Their Effects on Risk of Vascular and Metabolic Disease

摘要: Chronic fatty acid overload is a major determinant of vascular and metabolic diseases associated with excess western diet sedentary lifestyle. Beyond the complex traits behind diabetes obesity (diabesity), number rare genetic disorders related to mitochondrial peroxisomal function myopathies directly affect metabolism. The detailed molecular analysis these will provide deeper insight into determinants lipid Fatty acids are either synthesized de novo or taken up as nutrients. elongation desaturation follows several distinct pathways regulated by desaturases elongases. Unsaturated precursors for prostanoid synthesis, which have pro- anti-inflammatory -aggregatory -proliferative effects. differentially incorporated acylglycerols, cholesterylesters, glycerophospholipids sphingolipids, latter being membrane constituents but also involved in signalling regulation. b-oxidation mitochondria provides energy. Thus, metabolism result interaction remodelling some minor species other regulatory mechanisms.