Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities

摘要: The internal organs embedded in the cavities are lined by an epithelial monolayer termed mesothelium. mesothelium is increasingly implicated driving various organ pathologies, as many of normal embryonic developmental pathways acting mesothelial cells, such those regulating epithelial-to-mesenchymal transition, also drive disease progression adult life. Here, we summarize observations from different animal models and systems that collectively point toward a central role transition tissue fibrosis, acute scarring, cancer metastasis. Thus, drugs targeting mesothelium’s may have broad therapeutic benefits patients suffering these diseases. Tim Koopmans Yuval Rinkevich review recent findings linking programs epithelial-to-mesenchyme with They highlight new avenues for drug development would target mesenchymal transition.