High Hydrostatic Pressure Effects in the Biosphere: from Molecules to Microbiology

摘要: This chapter aims to give an outline of the effect high hydrostatic pressure on proteins, lipids, nucleic acids, and their interactions provide a thermodynamic kinetic framework describe these effects. The effects single-component systems (e.g., protein in solution) are then related viability microorganisms under extremes pressure. A temperature increase will cause volume expansion, reduction volume. If, however, as case water, forces strong, might actually decrease volume, is observed between 0 4°C, where it reaches its maximum density ambient conditions. above-mentioned general principles become even clearer when melting (dTm/dp) solid hydrocarbons ice considered. Proteins similar prion proteins involved bovine spongiform encephalopathy Creutzfeldt-Jakob’s disease also occur, for instance, yeasts. Mapping structural features biomolecules pressure-temperature plane important research topic molecular biologist see which state physiologically relevant.