The Role of Transposable Elements in the Origin and Evolution of MicroRNAs in Human
作者： Sheng Qin , Ping Jin , Xue Zhou , Liming Chen , Fei Ma
DOI: 10.1371/JOURNAL.PONE.0131365
关键词:
摘要: MicroRNAs (miRNAs) are crucial regulators of gene expression at the post-transcriptional level in eukaryotes via targeting 3'-untranslated regions. Transposable elements (TEs) considered as natural origins some miRNAs. However, what miRNAs and how these originate evolve from TEs remain unclear. We identified 409 TE-derived (386 overlapped with 23 un-overlapped TEs) which derived human. This indicates that play important roles origin In addition, we found proportions (MDTEs) human more than other vertebrates especially non-mammal vertebrates. Furthermore, classified MDTEs into three types TE head or tail sequences along adjacent genomic contribute to generation Our current study will improve understanding evolution
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