A double-blind, placebo-controlled trial of topiramate for pathological gambling

摘要: AbstractObjectives. Pathological gambling (PG) is an impulse control disorder characterized by recurrent thoughts and behaviours that impair social functioning. Earlier studies suggested topiramate may be effective in treating some disorders. We conducted the first randomized, controlled trial of PG. Methods. PG patients were randomized to (N = 20) or placebo 22) this 14-week, double-blind, placebo-controlled, parallel-group trial. The primary outcome measure was change obsessions subscale Yale-Brown Obsessive-Compulsive Scale Modified for Gambling. Results. Mixed regression models (time [weeks] × treatment) revealed no significant treatment effect on secondary measures. most statistically robust findings involved reducing Barratt Impulsiveness (BIS) total score Motor Non-Planning scores, which outperformed at merely a trend le...