PULSATILE GONADOTROPHIN SECRETION IN HYPERPROLACTINAEMIC AMENORRHOEA AND THE RESPONSE TO BROMOCRIPTINE THERAPY

摘要: SUMMARY Serum gonadotrophin concentrations were measured every 15 min for 8 h in six patients before and at weekly intervals during initiation of bromocriptine treatment hyperprolactinaemic amenorrhoea. Before mean levels similar to those found the normal follicular phase, but LH secretion was characterized by infrequent pulses large amplitude. In three subjects patterns pulsatility serum oestradiol returned within 7 days starting bromocriptine. The other responded with an increase frequency levels, little rise oestradiol. Thus some have a defect ovarian response endogenous stimulation, which may persist few weeks after return prolactin normal. restoration rate can occur without any change concentration.