Coronary Artery Vasculopathy in Pediatric Cardiac Transplant Patients

摘要: The single largest cause of late graft loss in pediatric cardiac transplantation is transplant coronary artery vasculopathy (CAV). mechanism CAV remains unknown; it appears to have both immune and non-immune causes. final common pathway these mechanisms endothelial activation, a prothrombotic environment, damage with subsequent diffuse intimal proliferation. disease process has largely been thought be progressive unresponsive treatment. Re-transplantation advocated as the only definitive appropriate management intervention or surgical had limited utility, while medical most promise. Improvement outcome can achieved by optimizing factors aggressive mechanisms. Long-term survival patients after diagnosis now being reported.