The overexpression of salivary cytokeratins as potential diagnostic biomarkers in head and neck squamous cell carcinomas

摘要: // Kai Dun Tang 1, 2 , Liz Kenny 3, 4 Chris Perry 5 Ian Frazer 6 and Chamindie Punyadeera 1 The School of Biomedical Sciences, Institute Health Innovation, Queensland University Technology, Kelvin Grove, Queensland, Australia Translational Research Institute, Woolloongabba, 3 Medicine, Royal Brisbane Women’s Hospital, Brisbane, Central Integrated Regional Cancer Service, Health, Department Otolaryngology, Princess Alexandra Diamantina Correspondence to: Punyadeera, email: chamindie.punyadeera@qut.edu.au Keywords: saliva, cytokeratin, head neck squamous cell carcinoma, human papillomavirus Received: May 17, 2017     Accepted: June 28, Published: July 31, 2017 ABSTRACT Background: Cytokeratin (CK) intermediate filaments are demonstrated to have enormous potential in regulating cellular motility cancer progression. There more than 20 divergent CKs that been identified, which CK 8, 18 19 reported be elevated the tumour biopsies carcinoma (HNSCC) patients. However, expression profiles saliva HNSCC patients not investigated. We aim investigate mRNA collected from healthy controls, HPV-negative -positive Methods: Oral rinse samples were 42 cancer-free controls (age-matched) who diagnosed with (n = 20) 48) HNSCC. Results: Here, we report differed levels 8 significantly patients; whilst, 17 expressed at a higher level HPV-positive compared controls. Importantly, receiver operating characteristic (ROC) analysis showed salivary superior sensitivity specificity discriminating (80% 86%) as well between (75% 81%). Conclusion: In summary, an aberrant may serve non-invasive diagnostic biomarker