Regulatory role of brain angiotensins in the control of physiological and behavioral responses

摘要: Considerable evidence now indicates that a separate and distinct renin-angiotensin system (RAS) is present within the brain. The necessary precursors enzymes required for formation degradation of biologically active forms angiotensins have been identified in brain tissues as angiotensin binding sites. Although this RAS appears to be regulated independently from peripheral RAS, circulating do exert portion their actions via stimulation receptors located circumventricular organs. These organs are proximity ventricles, richly vascularized possess reduced blood-brain barrier thus permitting accessibility by peptides. In way interacts with other neurotransmitter neuromodulator systems contributes regulation blood pressure, body fluid homeostasis, cyclicity reproductive hormones sexual behavior, perhaps plays role functions such memory acquisition recall, sensory acuity including pain perception exploratory behavior. An overactive has one factors contributing pathogenesis maintenance hypertension spontaneously hypertensive rat (SHR) model human essential hypertension. Oral treatment angiotensin-converting enzyme inhibitors, which interfere II, prevents development young SHR acting, at least part, upon RAS. Delivery converting inhibitors or specific receptor antagonists into significantly reduces pressure adult SHR. Thus, if an appropriate (there controversy concerning its usefulness), potential contribution dysfunction must considered during future antihypertensive compounds.