Antimicrobial Peptides of Lactoferrin
作者： Mamoru Tomita , Mitsunori Takase , Hiroyuki Wakabayashi , Wayne Bellamy
DOI: 10.1007/978-1-4615-2548-6_20
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摘要: Lactoferrin was found to contain an antimicrobial sequence near its N-terminus which appears function by a mechanism distinct from iron chelation. Antimicrobial peptides representing this domain were isolated following pepsin cleavage of human lactoferrin and bovine lactoferrin. The consist mainly loop 18 amino acid residues formed disulfide bond between cysteine 20 37 lactoferrin, or 19 36 identified contains high proportion basic residues, like various other known target microbial membranes it be located on the surface folded protein allowing interaction with components cells. domain, "lactoferrin", shown have potent broad spectrum properties effect lethal causing rapid loss colony-forming capability. Such evidence points conclusion that is structural region responsible for microbicidal also suggests possibility active produced enzymatic digestion may contribute host defense against disease.
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springerlink.com参考文章(24)
J. J. Bullen, Henry J. Rogers, E. Griffiths, Role of Iron in Bacterial Infection Modern Aspects of Electrochemistry. ,vol. 80, pp. 1- 35 ,(1978) , 10.1007/978-3-642-66956-9_1
Claudia Dalmastri, P. Visca, P. Valenti, N. Orsi, P. Vittorioso, Enhanced antimicrobial activity of lactoferrin by binding to the bacterial surface. Microbiologica. ,vol. 11, pp. 225- 230 ,(1988)
J R Kalmar, R R Arnold, Killing of Actinobacillus actinomycetemcomitans by human lactoferrin. Infection and Immunity. ,vol. 56, pp. 2552- 2557 ,(1988) , 10.1128/IAI.56.10.2552-2557.1988
R T Ellison, T J Giehl, F M LaForce, Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. Infection and Immunity. ,vol. 56, pp. 2774- 2781 ,(1988) , 10.1128/IAI.56.11.2774-2781.1988
Robert I Lehrer, Tomas Ganz, Michael E Selsted, Defensins: endogenous antibiotic peptides of animal cells. Cell. ,vol. 64, pp. 229- 230 ,(1991) , 10.1016/0092-8674(91)90632-9
Wayne Bellamy, Mitsunori Takase, Koji Yamauchi, Hiroyuki Wakabayashi, Kouzou Kawase, Mamoru Tomita, Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta. ,vol. 1121, pp. 130- 136 ,(1992) , 10.1016/0167-4838(92)90346-F
R. Arnold, M. Cole, McGhee, A bactericidal effect for human lactoferrin Science. ,vol. 197, pp. 263- 265 ,(1977) , 10.1126/SCIENCE.327545
H V Westerhoff, D Juretić, R W Hendler, M Zasloff, Magainins and the disruption of membrane-linked free-energy transduction Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 6597- 6601 ,(1989) , 10.1073/PNAS.86.17.6597
Annick PIERCE, Didier COLAVIZZA, Monique BENAISSA, Pierrette MAES, Andre TARTAR, Jean MONTREUIL, Genevieve SPIK, Molecular cloning and sequence analysis of bovine lactotransferrin. FEBS Journal. ,vol. 196, pp. 177- 184 ,(1991) , 10.1111/J.1432-1033.1991.TB15801.X
Richard A. Finkelstein, Carmen V. Sciortino, Mark A. McIntosh, Role of Iron in Microbe-Host Interactions Clinical Infectious Diseases. ,vol. 5, ,(1983) , 10.1093/CLINIDS/5.SUPPLEMENT_4.S759