Administration of erythropoietin fails to improve long-term healing or cardiac function after myocardial infarction in the rat.

摘要: Erythropoietin (epo), initially recognized and used clinically to increase erythropoiesis, has been shown have beneficial effects on various other tissues in the setting of hypoxia ischemia. Epo reduce apoptosis after myocardial infarction, but few studies evaluated long-term epo treatment left ventricular (LV) remodeling, cardiac function, blood flow healing a permanent coronary artery occlusion. The aim this study was assess healed heart 6 weeks infarction. Anesthetized rats underwent occlusion were treated with erythropoietin (5000 units/kg/day, n=21) or saline (n=20) day before surgery, of, then for 5 days. At LV ventriculography volumes ejection fractions histologic assessment infarct size cavity wall dimensions performed. Overall had no effect remodeling function. There significant differences morphology, (44+/-3% circumference versus 39+/-3%), area, scar thickness, systolic volume, fraction 39+/-3%) between groups, respectively. However, any given infarct, significantly higher hearts lower. Thus, our model, infarction may exerted some positive