Early murine polymicrobial sepsis predominantly causes renal injury.

摘要: Multiple organ failure in sepsis substantially increases mortality. This study examined if there was greater hepatic, pancreatic, splenic, or renal injury mice that would die during induced by cecal ligation and puncture (CLP) compared with of those survive. Mice were stratified into groups predicted to (Die-P) live (Live-P) the first 5 days after CLP based on plasma interleukin 6 levels. Groups sacrificed harvest organs for histology. Separate animals followed survival daily blood sampling examine function. No significant histological evidence observed either Live-P Die-P mice. Minimal hepatic occurred as aspartate transaminase demonstrated less than a 2-fold increase over normal both groups. In addition, pancreatic minimal also amylase contrast, urea nitrogen levels nearly five times higher within 24 h live. 44 mg/dL had 17.6 relative risk dying (95% confidence interval, 4.5-69.4). Cystatin C, more specific kidney function biomarker, elevated at CLP. When cystatin C analyzed hours before death, rather CLP, they significantly increased Dead day Alive 5. We conclude limited liver, pancreas, spleen develops murine CLP-induced while is present. The becomes worse closer death.