Cultured epidermal allografts as biological wound dressings.

摘要: Recent advances in cell culture technology permit the generation of large stratified epithelial sheets appropriate for wound coverage. Autografts (sheets prepared from patient's own skin) have proven life-saving treatment third-degree burns and been successfully employed management chronic ulcers. Allografts skin an unrelated donor) also used. In our experience, cultured allografts derived neonatal foreskin provide a potent stimulus to healing variety partial thickness wounds. Their application is simple outpatient procedure which involves no discomfort patient. contrast autografting, biopsy necessary use allogenic cells permits immediate grafts availability possibility stockpiling preserving future use. Preparation suitable grafting faster easier with newborn than adult donor cells. Newborn caused rapid most previously refractory ulcers long-term results comparable those obtained conventional split grafting. We postulate that act by providing temporary covering while releasing multiple cytokines synergistically promote permanent reepitheliazation quiescent host keratinocytes then stimulated divide migrate. Whether are immunologically rejected clinically undetectable reaction or simply replaced stochastically presently unknown.