Nitrite as endothelial NO donor under anoxia

摘要: Publisher Summary Nitrite anions ( NO 2 − ) appear as metastable intermediates in the oxidation cascade leading from nitric oxide (NO) radicals to stable metabolite nitrate 3 ). The occurrence of nitrite living tissues reflects metabolic fate oxidized nitrogen species organisms. have low molecular weight and show rapid diffusive transport water but cannot cross lipid cell membranes. Recent observations animals humans greatly increased interest possible biological functions nitrite, especially with respect blood flow vascular system. observation that may be converted into under conditions hypoxia attracted special interest. As such, is now considered act a hypoxic buffer assist maintaining vasodilation mitochondrial respiration hypoxia. Its importance stems abundance circulation. A rapidly increasing body clinical data attests protective action against ischemic damage other tissues. In this case, beneficial effect seems mediated by release free-NO or NO-like This chapter concentrates on mechanism behind effects when tissue subjected oxygen tension arise ischemia, hypoxia, anoxia.