Macrophages Recognize Size and Shape of Their Targets

摘要: Recognition by macrophages is a key process in generating immune response against invading pathogens. Previous studies have focused on recognition of pathogens through surface receptors present the macrophage's surface. Here, using polymeric particles different geometries that represent size and shape range variety bacteria, importance target geometry was investigated. The reported here reveal attachment to exhibits strong dependence shape. For all sizes shapes studied, possessing longest dimension 2–3 µm exhibited highest attachment. This also happens be most commonly found bacteria nature. features macrophages, particular membrane ruffles, might play an important role this geometry-based macrophages. These findings significant implications understanding pathogenicity designing drug delivery carriers.