Electric field-induced breakdown of lipid bilayers and cell membranes: a thin viscoelastic film model.

摘要: A simple viscoelastic film model is presented, which predicts a breakdown electric potential having dependence on the pulse length approximates available experimental data for of lipid bilayers and cell membranes (summarized in reviews U. Zimmermann J. Vienken, 1982,J. Membrane Biol. 67:165 Zimmermann, 1982,Biochim. Biophys. Acta 694:227). The basic result formula time τ membrane (up to formation pores): τ=α(μ/C)/(e m 2 e 0 U 4/24σGh 3+T 2/σGh−1), where α proportionality coefficient approximately equal ln(h/2ζ0),h being thickness ζ0 amplitude initial surface shape fluctuation (α usually order unity), μ represents shear viscosity,G elasticity modules, relative permittivity, e0=8.85×10−12 Fm,U across membrane, σ tension andT tension. This critical potentialU c ;U =(24σGh 3/e )1/4 (for τ=∞ andT=0). It proposed that course field-induced can be divided into three stages: (i) growth fluctuations, (ii) molecular rearrangements leading discontinuities, (iii) expansion pores, resulting mechanical membrane.