Quality of life during chemotherapy in patients with symptomatic advanced colorectal cancer

摘要: Background. To increase the knowledge about palliative effects of chemotherapy in patients with symptomatic advanced colorectal cancer, physician- and patient-rated “quality life” was studied a randomized multicenter trial comparing regimen methotrexate/5-fluorouracil (5-FU) followed by leucovorin rescue (MFL) 5-FU/leucovorin (FLv). Methods. Between January 1989 December 1990, 70 completed quality life questionnaire at randomization after every fourth treatment course. At one hospitals, evaluation done as an interview (interview group, n = 24), whereas used other hospitals (questionnaire 46). Results. Objective responses (complete response plus partial response) were obtained 15 (21%) patients, subjective 29 (41%) overall improved 25 (36%) patients. In addition, 16 (23%) had unchanged during least 4 months. There correlation between objective responses, improvements life, although discrepancies noticed, particularly only slight symptoms. Response rates higher group than (P < 0.01). This difference could be related to more favorable outcome when 5-FU given bolus injection, rather short-term infusion (more 5 minutes). Conclusions. Improvements or prolonged stabilization disease can achieved half tumor-related However, factors administration may influence this proportion.