Tumor Microenvironment: Aspects of Stromal-Parenchymal Interaction
作者： Attila Zalatnai
DOI: 10.1007/978-1-4020-9576-4_2
关键词:
摘要: Solid tumors are composed of malignant parenchymal cells embedded in nonneoplastic stroma. A large body evidence emphasizes that the actual biological behavior given tumor is determined by continuous and mutual molecular interactions between stromal matrix, as well cells. Cancer create their own microenvironment, which promotes or suppresses growth, invasion spread The scenario highly complex, because there numerous not jut parenchyma stroma, but also extracellular matrix elements. These microenvironmental changes usually serve a selection advantage for growths, therefore, recently stroma-targeted novel therapeutic strategies being investigated.
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