Multiple mechanisms of B cell immunoregulation in man after administration of in vivo corticosteroids.

摘要: Despite the extensive clinical use of corticosteroids (CS) in treatment immune-mediated diseases, relatively little is known concerning effects CS on B cell function as measured by vitro assays. The single-dose vs several days vivo therapy spontaneous and mitogen-induced Ig production human peripheral blood cells are reported here. Spontaneous individual was enhanced an plaque-forming (PFC) assay. same increased response also observed with a brief exposure to CS, which suggests that mere active analogue all required produce response. immunoregulatory more complex. Pokeweed PFC responses were suppressed 4 5 hr after single pharmacologic dose complete recovery 24 hr. In contrast, 5-day course did not recover until 60 last dose. Moreover, mechanisms suppression operative. Ten hours completing there relative enrichment compartment lymphocytes bearing OKT8 suppressor/cytotoxic T phenotype coincided depressed At 36 dose, lymphocyte profile returned normal while remained suppressed. complex, multifaceted modulation immune response, resulting from redistribution subsets well altered functions, vary time-dose parameters administration. These observations should provide additional insights into heterogeneity CS-induced therapeutic effects.