Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats.
作者： Holger Klammer , Christiane Schlecht , Wolfgang Wuttke , Hubertus Jarry
DOI: 10.1016/J.TOX.2005.06.026
关键词:
摘要: Sun protection products contain a variety of UV-filters, among others, octyl-methoxycinnamate (OMC). Recently, an uterotrophic effect in immature rats has been reported, indicating that OMC might have estrogenic properties and thus is endocrine active chemical (EAC). However, determination activity the uterus only restricted approach with potential risk missing undesirable actions other organs regulated by estrogens. A pharmacodynamic experiment 5 dosages adult ovariectomized (ovx) was carried out to quantify multi-organic OMC. As control compound, estradiol-valerate (E2) included. Animals were treated per gavage for days. The expression levels markers action several measured RT-PCR. Effects on metabolic parameters assessed serum concentrations leptin, cholesterol, high low density lipoproteins (HDL LDL), glucose triglycerides. Observed changes upon treatment analyzed using NO(A)EL benchmark dose approach. From obtained data most sensitive parameter (truncated estrogen receptor protein 1 gene pituitary) we threshold values are exceeded recommended use containing formulations skin humans, therefore propose reduce cosmetic products. In addition OMC, non-estrogenic effects found this supporting need assessment putative EACs.
elsevier.com
sci-hub.se 参考文章(14)
M. Ponglikitmongkol, S. Green, P. Chambon, Genomic organization of the human oestrogen receptor gene. The EMBO Journal. ,vol. 7, pp. 3385- 3388 ,(1988) , 10.1002/J.1460-2075.1988.TB03211.X
M Schlumpf, B Cotton, M Conscience, V Haller, B Steinmann, W Lichtensteiger, In vitro and in vivo estrogenicity of UV screens. Environmental Health Perspectives. ,vol. 109, pp. 239- 244 ,(2001) , 10.1289/EHP.01109239
K. E. Friend, L. W. Ang, M. A. Shupnik, Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 4367- 4371 ,(1995) , 10.1073/PNAS.92.10.4367
Madoka Inui, Tetsuya Adachi, Shigeo Takenaka, Hiroshi Inui, Masami Nakazawa, Mitsuhiro Ueda, Hajime Watanabe, Chisato Mori, Taisen Iguchi, Kazutaka Miyatake, Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes) Toxicology. ,vol. 194, pp. 43- 50 ,(2003) , 10.1016/S0300-483X(03)00340-8
Richard Schreurs, Peter Lanser, Willem Seinen, Bart van der Burg, Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay Archives of Toxicology. ,vol. 76, pp. 257- 261 ,(2002) , 10.1007/S00204-002-0348-4
M.M Jiménez, J Pelletier, M.F Bobin, M.C Martini, Influence of encapsulation on the in vitro percutaneous absorption of octyl methoxycinnamate. International Journal of Pharmaceutics. ,vol. 272, pp. 45- 55 ,(2004) , 10.1016/J.IJPHARM.2003.11.029
D. Seidlová-Wuttke, H. Jarry, W. Wuttke, Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone. Toxicology. ,vol. 205, pp. 103- 112 ,(2004) , 10.1016/J.TOX.2004.06.042
Michael J Fasco, Estrogen receptor mRNA splice variants produced from the distal and proximal promoter transcripts Molecular and Cellular Endocrinology. ,vol. 138, pp. 51- 59 ,(1998) , 10.1016/S0303-7207(98)00048-3
George G. J. M. Kuiper, Bo Carlsson, Kaj Grandien, Eva Enmark, Johan Häggblad, Stefan Nilsson, Jan-Åke Gustafsson, COMPARISON OF THE LIGAND BINDING SPECIFICITY AND TRANSCRIPT TISSUE DISTRIBUTION OF ESTROGEN RECEPTORS ALPHA AND BETA Endocrinology. ,vol. 138, pp. 863- 870 ,(1997) , 10.1210/ENDO.138.3.4979
Nadeem Rezaq Janjua, Brian Mogensen, Anna-Maria Andersson, Jørgen Holm Petersen, Mette Henriksen, Niels E. Skakkebæk, Hans Christian Wulf, Systemic Absorption of the Sunscreens Benzophenone-3, Octyl-Methoxycinnamate, and 3-(4-Methyl-Benzylidene) Camphor After Whole-Body Topical Application and Reproductive Hormone Levels in Humans Journal of Investigative Dermatology. ,vol. 123, pp. 57- 61 ,(2004) , 10.1111/J.0022-202X.2004.22725.X