GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.
作者： C.M. Crews , J.L. Collins , W.S. Lane , M.L. Snapper , S.L. Schreiber
DOI: 10.1016/S0021-9258(17)40692-2
关键词:
摘要: … 49-kDa guanine nucleotide-binding elongation factor, EF-1 alpha, which was identified by … -1 alpha only in the presence of GTP but does not inhibit the GTPase activity of EF-1 alpha. …
elsevier.com
sci-hub.st 参考文章(33)
Michael Gschwendt, Walter Kittstein, Friedrich Marks, The Immunosuppressant FK-506, like Cyclosporins and Didemnin B, Inhibits Calmodulin-Dependent Phosphorylation of the Elongation Factor 2 in vitro and Biol Immunobiology. ,vol. 179, pp. 1- 7 ,(1989) , 10.1016/S0171-2985(89)80002-6
S W Whiteheart, P Shenbagamurthi, L Chen, R J Cotter, G W Hart, Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha. Journal of Biological Chemistry. ,vol. 264, pp. 14334- 14341 ,(1989) , 10.1016/S0021-9258(18)71682-7
Jolanda H. G. M. BRANDS, J. Antonie MAASSEN, Formijn J. HEMERT, Reinout AMONS, Wim MOLLER, The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites. FEBS Journal. ,vol. 155, pp. 167- 171 ,(1986) , 10.1111/J.1432-1033.1986.TB09472.X
J W Hershey, Protein phosphorylation controls translation rates. Journal of Biological Chemistry. ,vol. 264, pp. 20823- 20826 ,(1989) , 10.1016/S0021-9258(19)30005-5
S. Hoshino, H. Miyazawa, T. Enomoto, F. Hanaoka, Y. Kikuchi, A. Kikuchi, M. Ui, A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. The EMBO Journal. ,vol. 8, pp. 3807- 3814 ,(1989) , 10.1002/J.1460-2075.1989.TB08558.X
Y. Kikuchi, H. Shimatake, A. Kikuchi, A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain. The EMBO Journal. ,vol. 7, pp. 1175- 1182 ,(1988) , 10.1002/J.1460-2075.1988.TB02928.X
Dong M Shin, Paul Y Holoye, William K Murphy, Arthur Forman, Sozos C Papasozomenos, None, Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting. Cancer Chemotherapy and Pharmacology. ,vol. 29, pp. 145- 149 ,(1991) , 10.1007/BF00687325
W. S. Lane, A. Galat, M. W. Harding, S. L. Schreiber, Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. Journal of Protein Chemistry. ,vol. 10, pp. 151- 160 ,(1991) , 10.1007/BF01024778
Bent Riis, Suresh I.S. Rattan, Brian F.C. Clark, William C. Merrick, Eukaryotic protein elongation factors. Trends in Biochemical Sciences. ,vol. 15, pp. 420- 424 ,(1990) , 10.1016/0968-0004(90)90279-K
Kenneth L. Rinehart, Vimal Kishore, Srinivasan Nagarajan, Robin J. Lake, James B. Gloer, Frank A. Bozich, Kai Ming Li, Robert E. Maleczka, William L. Todsen, Total synthesis of didemnins A, B, and C Journal of the American Chemical Society. ,vol. 109, pp. 6846- 6848 ,(1987) , 10.1021/JA00256A046