Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study

摘要: Introduction The cytotoxic effects of radiation therapy are mediated primarily through increased formation hydroxyl radicals and reactive oxygen species, which can damage cells, proteins DNA; the glutathione S-transferases (GSTs) function to protect against oxidative stress. We hypothesized that polymorphisms encoding reduced or absent activity in GSTs might result greater risk for radiation-associated toxicity.