Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth.

摘要: Adult stem cells have attracted scientific attention because they are able to self-renew and differentiate into several specialized cell types. In this context, human dental tissue-derived mesenchymal (hDT-MSCs) emerged as a possible solution for repairing or regenerating damaged tissues. These can be isolated from primary teeth that naturally replaced, third molars, other tissues exhibit self-renewal, high proliferative rate great multilineage potential. However, the cellular molecular mechanisms determine lineage specification still largely unknown. It is known change in fate requires deletion of existing transcriptional programs, followed by establishment new developmental program give rise lineage. Increasing evidence indicates chromatin structure conformation influence fate. way, reversible chemical modifications at DNA histone level, combinations thereof activate inactivate cell-type-specific gene sequences, giving an alternative fates. On hand, miRNAs starting emerge player establishing particular somatic lineages. review, we discuss two promising research fields medicine biology, epigenetics cells, summarizing properties hDT-MSCs highlighting recent findings on epigenetic contributions regulation differentiation.