Atlas construction of cardiac fiber architecture using a multimodal registration approach

摘要: Abstract Cardiac fibers have a quite complex and interesting spatial structure the myocardial fiber orientation provides great effort on both cardiac research studies further clinical applications. Diffusion magnetic resolution imaging is unique methodology for non-invasively investigating myofiber architecture, e.g., diffusion tensor imaging. Accurate quantitative mapping of still challenging. In this study, statistical atlas constructed from seven subjects that were acquired by weighted scans. The reconstruction work based multimodal framework which involves most advances in image analysis methods: level-sets segmentation, multi-modal registration symmetric diffeomorphic nonlinear registration, averaging accurate analysis. Experimental results demonstrate helix angle variation markedly correlated with transmural wall depth its values vary 45° endocardium to −40° epicardium, whilst it 26° −29° epicardium traditional averaged atlas. proposed construction approach can effectively retain water anisotropic information, especially tissue edges, common known limit current techniques. Moreover, we find fractional anisotropy (FA) (0.55 ± 0.10) was higher than one (0.42 ± 0.05). Substantial differences found between FA (P = 0.02). Mean diffusivity (MD) (0.76 ± 0.05 × 10−3 mm2/s) significantly lower average (0.80 ± 0.12 × 10−3 mm2/s), P = 0.03. This study illustrates description may provide powerful tool assess micro-structure tissue.