HIV Immunosuppression and Antimalarial Efficacy: Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Malaria in HIV-Infected Adults in Siaya, Kenya

摘要: Background. The altered immune response of persons with human immunodeficiency virus (HIV) infection could result in increased rates antimalarial treatment failure. We investigated the influence HIV on to sulfadoxine-pyrimethamine treatment. Methods. Febrile adults Plasmodium falciparum parasitemia were treated and monitored for 28 days. status CD4 cell count determined at study enrollment. Results. Of enrolled study, 508 attended all follow-up visits, including 130 HIV-uninfected adults, 256 HIV-infected a high (200 cells/mL), 122 low (!200 cells/mL). hazard failure day was significantly higher (20.5%) than (7.7%). Anemia (hemoglobin level, !110 g/L) modified effect When we controlled fever parasite density, anemia 3.4 times that (adjusted ratio, 3.38; 95% confidence interval, 1.56‐7.34). Conclusions. have an risk malaria must be carefully monitored. Proven measures control prevention incorporated into basic package services provided by HIV/acquired syndrome care programs malarious areas.