Sensing Muscle Ischemia: Coincident Detection of Acid and ATP via Interplay of Two Ion Channels

摘要: Summary Ischemic pain—examples include the chest pain of a heart attack and leg 30 s sprint—occurs when muscle gets too little oxygen for its metabolic need. Lactic acid cannot act alone to trigger ischemic because pH change is so small. Here, we show that another compound released from muscle, adenosine tri-phosphate (ATP), works together with by increasing sensitivity acid-sensing ion channel number 3 (ASIC3), molecule used sensory neurons detect lactic acidosis. Our data argue ATP acts binding P2X receptors form molecular complex ASICs; receptor on appears be P2X5, an electrically quiet channel. Coincident detection should confer selectivity ischemia over other conditions