Studies on Sustained Release IV: Inert Matrix Tablets of Sulfamethizole, Employing Pdlyvinyl Chloride and Carboxypolymethylene

摘要: AbstractAn inert matrix type sulfamethizole sustained release dosage form is attempted, using polyvinyl chloride and carboxypolymethylene. The obtained with the flow -through cell lower than target profile. With rotating bottle apparatus, higher rates were obtained, but based upon our previous findings, latter method considered not to be very realistic.Upon kinetic assessment of dissolution data, zero order, first order Hixson-Crowell kinetics found give similar fits.