Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer
作者： Zhong-Qiang Guo , Tong Zheng , Baoen Chen , Cheng Luo , Sisheng Ouyang
DOI: 10.1016/J.CCELL.2016.08.003
关键词:
摘要: In the cytoplasm of virtually all clear-cell renal cell carcinoma (ccRCC), speckle-type POZ protein (SPOP) is overexpressed and misallocated, which may induce proliferation and …
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Emil Bulatov, Alessio Ciulli, Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. Biochemical Journal. ,vol. 467, pp. 365- 386 ,(2015) , 10.1042/BJ20141450
Yi Sun, E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia. ,vol. 8, pp. 645- 654 ,(2006) , 10.1593/NEO.06376
Keiichi I. Nakayama, Keiko Nakayama, Ubiquitin ligases: cell-cycle control and cancer Nature Reviews Cancer. ,vol. 6, pp. 369- 381 ,(2006) , 10.1038/NRC1881
Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi, Ziya Kirkali, 2004 WHO Classification of the Renal Tumors of the Adults European Urology. ,vol. 49, pp. 798- 805 ,(2006) , 10.1016/J.EURURO.2005.11.035
Qing Zhang, Lei Zhang, Bing Wang, Chan-Yen Ou, Cheng-Ting Chien, Jin Jiang, A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor Developmental Cell. ,vol. 10, pp. 719- 729 ,(2006) , 10.1016/J.DEVCEL.2006.05.004
I. Hernandez-Munoz, A. H. Lund, P. van der Stoop, E. Boutsma, I. Muijrers, E. Verhoeven, D. A. Nusinow, B. Panning, Y. Marahrens, M. van Lohuizen, Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 7635- 7640 ,(2005) , 10.1073/PNAS.0408918102
Min Zhuang, Matthew F. Calabrese, Jiang Liu, M. Brett Waddell, Amanda Nourse, Michal Hammel, Darcie J. Miller, Helen Walden, David M. Duda, Steven N. Seyedin, Timothy Hoggard, J. Wade Harper, Kevin P. White, Brenda A. Schulman, Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases Molecular Cell. ,vol. 36, pp. 39- 50 ,(2009) , 10.1016/J.MOLCEL.2009.09.022
Gordon Saksena, Douglas Voet, Wasay M Hussain, Alex H Ramos, Wendy Winckler, Michelle C Redman, Kristin Ardlie, Ashutosh K Tewari, Juan Miguel Mosquera, Niels Rupp, Peter J Wild, Holger Moch, Colm Morrissey, Peter S Nelson, Philip W Kantoff, Stacey B Gabriel, Todd R Golub, Matthew Meyerson, Eric S Lander, Gad Getz, Mark A Rubin, Levi A Garraway, Christopher E Barbieri, Sylvan C Baca, Michael S Lawrence, Francesca Demichelis, Mirjam Blattner, Jean-Philippe Theurillat, Thomas A White, Petar Stojanov, Eliezer Van Allen, Nicolas Stransky, Elizabeth Nickerson, Sung-Suk Chae, Gunther Boysen, Daniel Auclair, Robert C Onofrio, Kyung Park, Naoki Kitabayashi, Theresa Y MacDonald, Karen Sheikh, Terry Vuong, Candace Guiducci, Kristian Cibulskis, Andrey Sivachenko, Scott L Carter, Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer Nature Genetics. ,vol. 44, pp. 685- 689 ,(2012) , 10.1038/NG.2279
James Brugarolas, Renal-Cell Carcinoma — Molecular Pathways and Therapies The New England Journal of Medicine. ,vol. 356, pp. 185- 187 ,(2007) , 10.1056/NEJME068263
Yi Sun, Targeting E3 ubiquitin ligases for cancer therapy. Cancer Biology & Therapy. ,vol. 2, pp. 623- 629 ,(2003) , 10.4161/CBT.2.6.677